PHARMACY MCQ AND NPC EXAM DAILY SERIES 43

 

MCQ FOR PHARMACY

1. An alcoholic or hydro-alcoholic (more than 60%
alcohol) solutions of volatile substance is known …………………

A. Elixir

B. Spirit

C. Gargle

D. Tincture

2. The application of liquid into rectum through the
anus for cleansing, for stimulating evacuation of the bowels, or for other
therapeutic or diagnostic purposes is known as………………………….

A. Enemas

B. Suppositories

C. Pessaries

D. Implants

3. ……………. mill is used to reduce particle size of
sticky materials.

A. Rod

B. Fluid energy

C. Ball

D. Pin

4. If the drug distribute instantly throughout the body,
the drug follows ………….. compartment model.

A. One

B. Non

C. Two

D. Three

5. ………………. is required to calculate loading dose:

A. AUC

B. Vd

C. Clearance

D. Cpmax

6. BCS class …………. drug are having low solubility and
high permeability.

A. I

B. II

C. III

D. IV

7. To achieve proper coating, spray angle should be
kept at …………….º with the tablet bed.

A. 60

B. 45

C. 30

D. 90

8. In this glass, the surface is treated with sulphur
dioxide;

A. Type I

B. Type III

C. Type II

D. Type IV

9. Hausner’s ratio between 1.12-1.18 indicates…

A. Excellent flow

B. Poor flow

C. Good flow

D. Very Poor flow

10. The main part of punch which receives compression
force from roller is;

A. Head

B. Head flat

C. Barrel

D. Inside Head angle

11. During pre-formulation studies, intrinsic solubility
of a drug is measured at… A. 4°C and 37°C

B. -4°C and 37°C

C. 8°C and 40°C

D. -8°C and 40°C

12. Tabletose is:

A. Starch

B. Direct compressible starch

C. Direct compressible lactose

D. Dicalcium Phosphate

13. According to IP, the disintegration time of
enteric coated tablet in mixed phosphate buffer (pH 6.8) after testing in
0.1MHCl is;

A. 1 hour

B. 30 minute

C. 2 hour

D. 45 minute

14. which of the following is absorption base used to
make ointment?

A. Hard Soft Paraffin

B. Poly ethylene glycol

C.Anhydrous Lanolin

D. White ointment

15. The area under the serum concentration versus time
curve represents

A. Biological half life

B. Amount of drug cleared by kidneys

C. Amount of drug in original dosage form

D. Amount of drug absorbed

16. PDCA cycle in quality means

A. Prepare, Do, Check and Act

B. Perform, Do, Check and Act

C. Plan, Do, Check and Act

D. Proceed, Do, Check and Assure

17. Wetting ability of vehicle is detected by
observing…

A. Contact angle

B. Critical angel  

C. Angle of repose

D. Carr’s index

18. The substance which increase the viscosity of the
continuous phase in a suspension is known as:

A. Suspending agent

B. Flocculating agent

C. Wetting agent

D. Dispersing agents

19. Carr’s Consolidation index 5-10% means …………………….
Flow property. A. Excellent

B. Good

C. Fair

D. Poor

20. …………… is used to cut DNA molecule in rDNA
technology

A. Ligase

B. Ribonuclease

C. Phosphatase

D. Restriction enzymes

21. PPE in biosafety is …………

A. Public protective equipment

B. Personal Protective Equipment

C. Possible protective equipment

D. Passable protective equipment

22. The Best method for Aspirin Tablet manufacturing
is:

A. Wet granulation

B. Aqueous manual granulation

C. Aqueous auto processing

D. Dry granulation

23. Decrease in moisture content of empty capsule
below 10% can render the capsule ………

A. Brittle

B. Flexible

C. Sticky

D.Colorless

24. Filler is synonymous to………………….

A. Binder

B. Disintegrant

C. Diluents

D. Glidant

25. In …… both heat and pressure are used.

A. Digestion

B. Infusion  

C. Decoction

D. Maceration

For Answer click on image:

 

1. What is the difference between a solution, suspension, and elixir?

Solution: A clear, homogenous liquid preparation where the drug is completely dissolved.
Suspension: A liquid dosage form containing finely divided insoluble drug particles dispersed in a liquid.
Elixir: A clear, sweetened, hydroalcoholic liquid used for oral administration of medications.

2. What is the primary function of a disintegrant in tablet formulation?

Disintegrants help the tablet break down into smaller particles in the digestive system, aiding in faster drug absorption.

3. What are enteric-coated tablets, and why are they used?

Enteric-coated tablets have a special coating that prevents them from dissolving in stomach acid, ensuring drug release in the intestines. This protects the drug from stomach acids and reduces gastric irritation.

4. What is the difference between a diluent and a binder in tablet formulation?

Diluent: Increases the tablet’s bulk, making it easier to compress. Example: Lactose, Microcrystalline cellulose.
Binder: Helps hold the tablet ingredients together, improving cohesiveness. Example: Starch, Gelatin.

5. What is the role of preservatives in syrups?

Preservatives prevent microbial growth and extend the shelf life of liquid formulations. Example: Methylparaben, Benzoic acid.

6. Why is insulin administered subcutaneously and not orally?

Insulin is a protein that gets broken down by digestive enzymes when taken orally, making it ineffective. Subcutaneous administration ensures proper absorption into the bloodstream.

7. What are BCS classification classes in drug solubility and permeability?

Class I: High solubility, high permeability.
Class II: Low solubility, high permeability.
Class III: High solubility, low permeability.
Class IV: Low solubility, low permeability.

8. What is the function of a wetting agent in pharmaceutical formulations?

Wetting agents reduce the surface tension of liquids, improving the mixing and dispersion of solid particles in suspensions. Example: Polysorbates.

9. Why are beta-blockers contraindicated in bronchial asthma?

Beta-blockers can cause bronchoconstriction, which worsens asthma symptoms by blocking beta-2 receptors in the lungs.

10. What is the difference between bioavailability and bioequivalence?

Bioavailability: The proportion of a drug that reaches systemic circulation in an active form.
Bioequivalence: Two drugs are bioequivalent if they show similar bioavailability and therapeutic effects at the same dose.

11. What is the function of restriction enzymes in rDNA technology?

Restriction enzymes cut DNA at specific sequences, allowing scientists to manipulate genetic material for research and medical applications.

12. What is the purpose of using excipients in tablet manufacturing?

Excipients improve drug stability, aid in drug release, enhance compressibility, and ensure uniform drug distribution.

13. What is the difference between an ointment and a cream?

Ointment: Oil-based, greasy, and provides a protective barrier.
Cream: Water-based or oil-in-water emulsion, spreads easily and absorbs faster.

14. What is the PDCA cycle in quality control?

PDCA (Plan-Do-Check-Act) is a continuous improvement process used in quality management to enhance product consistency and effectiveness.

15. What are some common side effects of cytotoxic drugs?

Side effects include nausea, vomiting, alopecia (hair loss), myelosuppression, and immune suppression.

16. What is the difference between a pessary and a suppository?

Pessary: A solid dosage form inserted into the vagina.
Suppository: A solid dosage form inserted into the rectum or urethra.

17. Why are organophosphate poisonings treated with atropine?

Organophosphates inhibit acetylcholinesterase, leading to excessive acetylcholine accumulation. Atropine blocks acetylcholine receptors, reducing symptoms.

18. What is Hausner’s ratio, and what does it indicate?

Hausner’s ratio is a measure of powder flowability:
<1.25: Good flow
1.25–1.5: Poor flow
>1.5: Very poor flow

19. What is an expectorant, and how does it work?

Expectorants help clear mucus from the airways by increasing its production and making it easier to expel. Example: Guaifenesin.

20. Why are vitamins B6 and isoniazid given together?

Isoniazid depletes vitamin B6 (pyridoxine), which can cause neuropathy. Giving B6 prevents this side effect.

{
“@context”: “https://schema.org”,
“@type”: “FAQPage”,
“mainEntity”: [
{
“@type”: “Question”,
“name”: “What is the difference between a solution, suspension, and elixir?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Solution: A clear, homogenous liquid preparation where the drug is completely dissolved. Suspension: A liquid dosage form containing finely divided insoluble drug particles dispersed in a liquid. Elixir: A clear, sweetened, hydroalcoholic liquid used for oral administration of medications.”
}
},
{
“@type”: “Question”,
“name”: “What is the primary function of a disintegrant in tablet formulation?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Disintegrants help the tablet break down into smaller particles in the digestive system, aiding in faster drug absorption.”
}
},
{
“@type”: “Question”,
“name”: “What are enteric-coated tablets, and why are they used?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Enteric-coated tablets have a special coating that prevents them from dissolving in stomach acid, ensuring drug release in the intestines. This protects the drug from stomach acids and reduces gastric irritation.”
}
},
{
“@type”: “Question”,
“name”: “What is the difference between a diluent and a binder in tablet formulation?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Diluent: Increases the tablet’s bulk, making it easier to compress. Example: Lactose, Microcrystalline cellulose. Binder: Helps hold the tablet ingredients together, improving cohesiveness. Example: Starch, Gelatin.”
}
},
{
“@type”: “Question”,
“name”: “What is the role of preservatives in syrups?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Preservatives prevent microbial growth and extend the shelf life of liquid formulations. Example: Methylparaben, Benzoic acid.”
}
},
{
“@type”: “Question”,
“name”: “Why is insulin administered subcutaneously and not orally?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Insulin is a protein that gets broken down by digestive enzymes when taken orally, making it ineffective. Subcutaneous administration ensures proper absorption into the bloodstream.”
}
},
{
“@type”: “Question”,
“name”: “What are BCS classification classes in drug solubility and permeability?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Class I: High solubility, high permeability. Class II: Low solubility, high permeability. Class III: High solubility, low permeability. Class IV: Low solubility, low permeability.”
}
},
{
“@type”: “Question”,
“name”: “What is the function of a wetting agent in pharmaceutical formulations?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Wetting agents reduce the surface tension of liquids, improving the mixing and dispersion of solid particles in suspensions. Example: Polysorbates.”
}
},
{
“@type”: “Question”,
“name”: “Why are beta-blockers contraindicated in bronchial asthma?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Beta-blockers can cause bronchoconstriction, which worsens asthma symptoms by blocking beta-2 receptors in the lungs.”
}
},
{
“@type”: “Question”,
“name”: “What is the difference between bioavailability and bioequivalence?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Bioavailability: The proportion of a drug that reaches systemic circulation in an active form. Bioequivalence: Two drugs are bioequivalent if they show similar bioavailability and therapeutic effects at the same dose.”
}
},
{
“@type”: “Question”,
“name”: “What is the function of restriction enzymes in rDNA technology?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Restriction enzymes cut DNA at specific sequences, allowing scientists to manipulate genetic material for research and medical applications.”
}
},
{
“@type”: “Question”,
“name”: “What is the purpose of using excipients in tablet manufacturing?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Excipients improve drug stability, aid in drug release, enhance compressibility, and ensure uniform drug distribution.”
}
},
{
“@type”: “Question”,
“name”: “What is the difference between an ointment and a cream?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Ointment: Oil-based, greasy, and provides a protective barrier. Cream: Water-based or oil-in-water emulsion, spreads easily and absorbs faster.”
}
},
{
“@type”: “Question”,
“name”: “What is the PDCA cycle in quality control?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “PDCA (Plan-Do-Check-Act) is a continuous improvement process used in quality management to enhance product consistency and effectiveness.”
}
},
{
“@type”: “Question”,
“name”: “What are some common side effects of cytotoxic drugs?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Side effects include nausea, vomiting, alopecia (hair loss), myelosuppression, and immune suppression.”
}
},
{
“@type”: “Question”,
“name”: “What is the difference between a pessary and a suppository?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Pessary: A solid dosage form inserted into the vagina. Suppository: A solid dosage form inserted into the rectum or urethra.”
}
},
{
“@type”: “Question”,
“name”: “Why are organophosphate poisonings treated with atropine?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Organophosphates inhibit acetylcholinesterase, leading to excessive acetylcholine accumulation. Atropine blocks acetylcholine receptors, reducing symptoms.”
}
},
{
“@type”: “Question”,
“name”: “What is Hausner’s ratio, and what does it indicate?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Hausner’s ratio is a measure of powder flowability: <1.25: Good flow, 1.25–1.5: Poor flow, >1.5: Very poor flow.”
}
},
{
“@type”: “Question”,
“name”: “What is an expectorant, and how does it work?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Expectorants help clear mucus from the airways by increasing its production and making it easier to expel. Example: Guaifenesin.”
}
},
{
“@type”: “Question”,
“name”: “Why are vitamins B6 and isoniazid given together?”,
“acceptedAnswer”: {
“@type”: “Answer”,
“text”: “Isoniazid depletes vitamin B6 (pyridoxine), which can cause neuropathy. Giving B6 prevents this side effect.”
}
}
] }